Roche is researching Hedgehog pathway inhibition because abnormal activation of this pathway plays an important role in the pathogenesis of several types of cancer, notably basal cell carcinoma (BCC) also known as basal cell cancer or basal skin cancer.1 Hedgehog pathway inhibitors may therefore provide a new treatment option for patients with BCC and for patients with other forms of cancer.1

This website is a central resource for medical professionals and basic and translational researchers with an interest in learning more about the Hedgehog pathway and its role in BCC.